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Pragmatic trials are those that are designed to inform the practice of clinical trials in real life. They are usually focused on the practical aspects of the study design, such as recruitment and consent, adherence, and the use of commonly available equipment.
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Pragmatic is a software developer that offers a broad range of casino games for online gambling platforms. Its iGaming software is used by the top operators as well as land-based casinos. The company provides front-end design tools, analysis, marketing, promotions payment systems, security, customer service, and bug reporting. Additionally, the company offers its players a safe and secure environment that features high-quality graphics and gaming.
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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which employed various investigators and included participants from different geographic areas. This type of heterogeneity which is vital for pragmatic trials to be reliable and to reduce bias in the results, is also necessary. However excessive heterogeneity could cause problems with the design of the trial.
Pragmatic Play is also a major player in the live casino market, offering a wide selection of classic table games such as Blackjack and Roulette in a variety of versions. Pragmatic Play's live studios in Romania and Malta offer an authentic gaming experience for its customers, as well as a full suite of virtual betting options. The company has also created various interactive games to make online gambling fun. Some of these shows are hosted live, while others feature famous personalities in the field.
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Pragmatic Play is a new player in the online casino market however, it has earned a name by offering mobile-friendly slots. Their games are optimised for mobile devices and are powered by HTML5 technology. They are also regulated and certified by respected gaming authorities, ensuring fairness and transparency. This is a great sign for players, as it means that the games are checked and verified to ensure that the outcomes of each round are random and unbiased.
Pragmatic Play offers not only mobile-friendly slot machines as well as live casino and table games. The company is licensed and regulated by a variety of governing bodies, including the Malta Gaming Authority and UK Gambling Commission. The games offered by the company are secured with high-end encryption and its security team is available to assist players with any issues.
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Legality
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Pragmatic trials are designed to replicate real-world situations and have the highest external validity. They are typically commissioned by policymakers and practitioners to inform their decisions. They are also a good method to determine the causality between an intervention and its results. However, they shouldn't be used to substitute for explanation trials.
The pragmatism concept is controversial, and there are doubts about whether pragmatic trials should replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which validate the clinical or physiological hypothesis and pragmatic trials that inform policy and practice decisions. They also proposed a framework for pragmatic trials, dubbed PRECIS.2 This tool sought to define the elements of a practical trial which includes the recruitment process, the design and delivery of the intervention, and the follow-up.
The number of pragmatic trials is increasing. A recent Medline search using the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. They are displayed in red on Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. However, it is important to remember that the majority of these trials were conducted in primary care settings.